LabImage used in Scientific Papers

LabImage in scientific papers

The following list is an abstract of papers published using LabImage software.  
So far more than 1000 papers used LabImage software.

Paper: Hepatoprotective effect of Physalis divaricata in paracetamol induced hepatotoxicity: In vitro, in silico and in vivo analysis

Abstract Ethnopharmacological relevance Physalis divaricata D. Don. is an erect weed of family Solanaceae. The root extract of this plant is used by the indigenous communities of Sub-Himalayan region of Uttarakhand, India for the treatment of liver disorders. Aim of the study To evaluate hepatoprotective potential of P. divaricata in paracetamol (PCM) induced hepatotoxicity in rats. Materials and methods The dried roots of P. divaricata were subjected to extraction using different solvents. The chloroform extract, methanol extract and bioactive aqueous fraction of methanol extract were evaluated for hepatoprotective effect. After initial in vitro screening, all extracts were screened for hepatoprotective...

Paper: Proteins in human body fluids contain in vivo antigen analog of the melibiose-derived glycation product: MAGE

Abstract Melibiose-derived AGE (MAGE) is an advanced glycation end-product formed in vitro in anhydrous conditions on proteins and protein-free amino acids during glycation with melibiose. Our previous studies revealed the presence of MAGE antigen in the human body and tissues of several other species, including muscles, fat, extracellular matrix, and blood. MAGE is also antigenic and induces generation of anti-MAGE antibody. The aim of this paper was to identify the proteins modified by MAGE present in human body fluids, such as serum, plasma, and peritoneal fluids. The protein-bound MAGE formed in vivo has been isolated from human blood using affinity...

Quality management system for ISO 13485 fully implemented according to the latest standards in software development

Kapelan Bio-Imaging GmbH is a developer and distributor of software solutions for digital image analysis in laboratory diagnostics based in Leipzig, Germany. The software is used in scientific and medical research as well as in clinical laboratory routine or in the pharmaceutical industry and is marketed worldwide. However, increasingly complex global networking of different players in the laboratory routine inevitably leads to increased requirements for internationally valid certifications for companies in this industry. The processes of laboratory diagnostics must not only be of high quality, but above all must comply with globally valid standards in order to be equally transparent...

Paper: Omeprazole prevents stress induced gastric ulcer by direct inhibition of MMP-2/TIMP-3 interactions

Abstract The healing of damaged tissues in gastric tract starts with the extracellular matrix (ECM) remodeling by the action of matrix metalloproteinases (MMPs). Particularly, MMP-2 (gelatinase-A) maintains ECM structure and function by degrading type IV collagen, the major component of basement membranes and by clearing denatured collagen. The proteolytic activities of MMPs are critically balanced by endogenous tissue inhibitors of metalloproteinases (TIMPs) and disruption of this balance results in several diseases. The well-known drug omeprazole is a proton pump inhibitor used for curing gastric ulcer. However, the action of omeprazole in ECM remodeling on gastroprotection has never been explored. Herein,...

Paper: Human Coxsackie- and adenovirus receptor is a putative target of neutrophil elastase-mediated shedding

Abstract During viral-induced myocarditis, immune cells migrate towards the site of infection and secrete proteases, which in turn can act as sheddases by cleaving extracellular domains of transmembrane proteins. We were interested in the shedding of the Coxsackie- and adenovirus receptor (CAR) that acts as an entry receptor for both eponymous viruses, which cause myocarditis. CAR shedding by secreted immune proteases could result in a favourable outcome of myocarditis as CAR’s extracellular domain would be removed from the cardiomyocytes’ surface leading to decreased susceptibility to ongoing viral infections. Authors Leonie Herrmann, Louise Schelletter, Raimund Hoffrogge, Karsten Niehaus, Volker Rudolph &...

Professional metadata management with new LabImage 1D Metadata Extension

  With the new Metadata Extension, Kapelan Bio-Imaging provides an extension for the world-wide established LabImage 1D, which simplifies the input and handling of additional data (metadata). Users are enabled to quickly and efficiently store metadata for their 1D imaging analysis and use it for later searches. The cumbersome paper-based recording of experimental conditions, annotations, comparative evaluation, etc. will, thus, be outpaced. In particular, companies and institutes involved in drug development or drug screening are offered a flexible option for annotating and evaluating metadata in 1D imaging analyses that is compatible with established solutions. Among others, the LabImage 1D Metadata...

Paper: Hepatoprotective effect of Physalis divaricata in paracetamol induced hepatotoxicity: In vitro, in silico and in vivo analysis

Abstract Ethnopharmacological relevance Physalis divaricata D. Don. is an erect weed of family Solanaceae. The root extract of this plant is used by the indigenous communities of Sub-Himalayan region of Uttarakhand, India for the treatment of liver disorders.Aim of the study To evaluate hepatoprotective potential of P. divaricata in paracetamol (PCM) induced hepatotoxicity in rats.Materials and methods The dried roots of P. divaricata were subjected to extraction using different solvents. The chloroform extract, methanol extract and bioactive aqueous fraction of methanol extract were evaluated for hepatoprotective effect. After initial in vitro screening, all extracts were screened for hepatoprotective potential in...

New Release 4.5 of LabImage

Kapelan publishes new software version for LabImage, Long Term Support Version, risk assessment according to ISO 13485. With the version LabImage Core 4.5, the new release will be published right before Christmas. Kapelan used the time to make some optimizations to the LabImage software. A large part of the work was spent in device handling and their calibration as well as adjustments to the LabImage 1D. Small improvements have also been made to simplify routine work. With the introduction of a quality management system according to ISO 13485, a risk assessment and extended release notes are available with the release....

Statement for error in modul Log4J in LabImage

According to the assessment of the German Bundesamts für Informationssicherheit (BSI), the Java library Log4J contains critical errors that can lead to a serious threat in the area of IT security. This mainly affects server systems in which the module is used as part of the architecture. According to the BSI, only online systems can be affected. In the versions 2.0-beta9 up to and including 2.14.1 it is possible to execute remote code. Kapelan also uses the Log4J module for handling actions in 21 CFR Part 11 mode. Since the LabImage systems cannot be accessed online or via the web...

Quality management system according to the latest standards in software development

The worldwide increasing of standardization activities in laboratory routines also comes along with higher requirements for companies in the field of certification. Data analyses should be-come more comparable, of higher quality and reproducible. In order to meet these require-ments, Kapelan Bio-Imaging has been working on the implementation of a quality manage-ment system according to ISO 13485 (Medical Devices Directive) since the beginning of 2021. Although the previous processes were already valid, transparent, and predominantly met the requirements of ISO 13485, as a customer from the regulated market of pharmaceutical pro-duction also noted in the course of a supplier audit, the...