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Paper: Human Coxsackie- and adenovirus receptor is a putative target of neutrophil elastase-mediated shedding

AbstractDuring viral-induced myocarditis, immune cells migrate towards the site of infection and secrete proteases, which in turn can act as sheddases by cleaving extracellular domains of transmembrane proteins. We were interested in the shedding of the Coxsackie- and adenovirus receptor (CAR) that acts as an entry receptor for both eponymous viruses, which cause myocarditis. CAR shedding by secreted immune proteases could result in a favourable outcome of myocarditis as CAR’s extracellular domain would be removed from the cardiomyocytes’ surface leading to decreased susceptibility to ongoing viral infections.
AuthorsLeonie Herrmann, Louise Schelletter, Raimund Hoffrogge, Karsten Niehaus, Volker Rudolph & Martin Farr
Published onMolecular Biology Reports volume 49, pages 3213–3223 (2022)
LabImage InfoGel and Blot data was analyzed with LabImage 1D